Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis-Diamminedichloroplatinum (II)

A. Rachid Rahmouni (1) , A. Schwartz (1) , M. Leng (1)

1 CBM - Centre de biophysique moléculaire

Numerous studies support the concept that DNA is the likely target for the antitumor drug cis-diamminedichloroplatinum (II) (cis-DDP) (1–3). Most of the adducts formed in the reaction of cis-DDP and DNA have been identified (4–6). Two major adducts arise from an intrastrand cross-link between two adjacent guanine residues and between adjacent adenine and guanine residues. Minor adducts arise from intrastrand cross-links between two guanine residues separated by one base and from interstrand cross-links between two guanine residues.

Domaines: Sciences du Vivant [q-bio]

A. Rachid Rahmouni, A. Schwartz, M. Leng. Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis-Diamminedichloroplatinum (II). Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Proceedings of the Fifth International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Abano, Padua, ITALY - June 29–July 2, 1987, Springer US, pp.127-131, 1988. ⟨hal-02127164⟩