AGuIX ® from bench to bedside - Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

François Lux 1 Vu Long Tran 1 Eloise Thomas 1 Sandrine Dufort 2 Fabien Rossetti 1 Matteo Martini 1 Charles Truillet 1 Tristan Doussineau 3 Guillaume Bort 4 Franck Denat 5 Frédéric Boschetti 6 Goran Angelovski 7 Alexandre Detappe 8 Yannick Crémillieux 9 Nathalie Mignet 10 Bich-Thuy Doan 11 Benoit Larrat 12 Sébastien Mériaux 12 Emmanuel Barbier 13 Stéphane Roux 14 Peter Fries 15 Andreas Muller 16 Marie-Caline Abadjian 17 Carolyn Anderson Emmanuel Canet-Soulas Penelope Bouziotis 18 Muriel Barberi-Heyob 19 Céline Frochot 20 Camille Verry 1 Jacques Balosso 21 Michael Evans Jacqueline Sidi-Boumedine 22 Marc Janier 23 Karl Butterworth 24 Stephen Mcmahon 25 Kevin Prise 24 Marie-Thérèse Aloy 26 Dominique Ardail 27 Claire Rodriguez-Lafrasse 28 Erika Porcel 29 Sandrine Lacombe 29 Ross Berbeco 8 Awatef Allouch 30 Jean-Luc Perfettini 30 Cyrus Chargari 31, 32 Éric Deutsch 33, 32 Géraldine Le Duc 34 Olivier Tillement 1
31 Service d'oncologie-radiothérapie
Hôpital d'Instruction des Armées du Val de Grâce
Abstract : AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.
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Submitted on : Tuesday, May 7, 2019 - 5:53:31 PM
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François Lux, Vu Long Tran, Eloise Thomas, Sandrine Dufort, Fabien Rossetti, et al.. AGuIX ® from bench to bedside - Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. British Journal of Radiology, British Institute of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩. ⟨hal-02123136⟩



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