Solution structure of drosomycin, the first inducible antifungal protein from insects

Abstract : Drosomycin is the first antifungal protein characterized recently among the broad family of inducible peptides and proteins produced by insects to respond to bacterial or septic injuries. It is a small protein of 44 amino acid residues extracted from Drosophila melanogaster that exhibits a potent activity against filamentous fungi. Its three-dimensional structure in aqueous solution was determined using 1H 2D NMR. This structure, involving an alpha-helix and a twisted three-stranded beta-sheet, is stabilized by three disulfide bridges. The corresponding Cysteine Stabilized alpha beta (CS alpha beta) motif, which was found in other defense proteins such as the antibacterial insect defensin A, short- and long-chain scorpion toxins, as well as in plant thionins and potent antifungal plant defensins, appears as remarkably persistent along evolution.
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Céline Landon, Patrick Sodano, Charles Hetru, Jules Hoffmann, Marius Ptak. Solution structure of drosomycin, the first inducible antifungal protein from insects. Protein Science, Wiley, 1997, 6 (9), pp.1878-1884. ⟨10.1002/pro.5560060908⟩. ⟨hal-02121218⟩

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