Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study

Mickael Vourc'H (1) , Donatien Huard (1) , Fanny Feuillet (2, 1) , Gabrielle Baud (1) , Arthur Guichoux (1) , Marielle Surbled (1) , Melanie Tissot (1) , Anne Chiffoleau (1) , Christophe Guitton (3, 4) , Samir Jaber (5, 6) , Karim Asehnoune (7, 1)

1 CHU Nantes - Centre Hospitalier Universitaire de Nantes
2 Biostatistique, Recherche Clinique et Mesures Subjectives en Santé
3 Service Réanimation Médicale Polyvalente
4 Centre Hospitalier Le Mans (CH Le Mans)
5 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
6 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
7 Service d'anesthésie et réanimation chirurgicale [Nantes]

Although preoxygenation and airway management respond to precise algorithms, difficult intubation (DI) remains a daily challenge in intensive care units and in the operating rooms because of its frequent complications, including hypoxaemia. To prevent desaturation during DI, high-flow oxygenation by nasal cannula (HFNC) could prove beneficial. Indeed, contrary to standard preoxygenation device, it can be held in place throughout the intubation trying to perform apnoeic oxygenation during DI. Hence, recent guidelines recommend HFNC during DI, but its relevance has never been evaluated in this setting in a large randomised study until now.

Mots clés: anticipated difficult intubation; apneic oxygenation; fiberoptic intubation; high-flow nasal cannula; video-laryngoscopy

Domaines: Sciences du Vivant [q-bio]

Mickael Vourc'H, Donatien Huard, Fanny Feuillet, Gabrielle Baud, Arthur Guichoux, et al.. Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study. BMJ Open, 2019, 9 (4), pp.e025909. ⟨10.1136/bmjopen-2018-025909⟩. ⟨hal-02113869⟩