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Zero-Mode Waveguide Detection of Flow-Driven DNA Translocation through Nanopores

Abstract : We directly measure the flow-driven injection of DNA through nanopores at the level of single molecule and single pore using a modified zero-mode waveguide method. We observe a flow threshold independent of the pore radius, the DNA concentration, and length. We demonstrate that the flow injection of DNA in nanopores is controlled by an energy barrier as proposed in the de Gennes-Brochard suction model. Finally, we show that the height of the energy barrier is modulated by functionalizing the nanopores.
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https://hal.archives-ouvertes.fr/hal-02112333
Contributor : Univ Évry Hal <>
Submitted on : Friday, April 26, 2019 - 3:48:38 PM
Last modification on : Friday, September 18, 2020 - 3:31:17 AM

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Thomas Auger, Jérôme Mathé, Virgile Viasnoff, Gaëlle Charron, Jean-Marc Di Meglio, et al.. Zero-Mode Waveguide Detection of Flow-Driven DNA Translocation through Nanopores. Physical Review Letters, American Physical Society, 2014, 113 (2), pp.028302. ⟨10.1103/PHYSREVLETT.113.028302⟩. ⟨hal-02112333⟩

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