Differential Binding of Poly(ADP-Ribose) Polymerase-1 and JunD/Fra2 Accounts for RANKL-Induced Tcirg1 Gene Expression During Osteoclastogenesis

Guillaume E. Beranger (1) , David Momier (2) , Jean-Marie Guigonis (3) , Michel Samson (4) , Georges F. Carle (2) , Jean-Claude Scimeca (5)

1 GéPITOS - Génétique, physiopathologie et ingénierie du tissu osseux
2 GéPITOS - Génétique, physiopathologie et ingénierie du tissu osseux
3 GSM - Génétique et signalisation moléculaire
4 SeRAIC - Signalisation et Réponses aux Agents Infectieux et Chimiques
5 IBV - Institut de Biologie Valrose

We studied Tcirg1 gene expression on RANKL-induced osteoclastic differentiation of the mouse model RAW264.7 cells. We identified a mechanism involving PARP-1 inhibition release and JunD/Fra-2 binding, which is responsible for Tcirg1 gene upregulation.

Domaines: Biochimie [q-bio.BM]; Biologie moléculaire; Génomique, Transcriptomique et Protéomique [q-bio.GN]; Interactions cellulaires [q-bio.CB]; Cancer; Biomatériaux; Rhumatologie et système ostéo-articulaire

Guillaume E. Beranger, David Momier, Jean-Marie Guigonis, Michel Samson, Georges F. Carle, et al.. Differential Binding of Poly(ADP-Ribose) Polymerase-1 and JunD/Fra2 Accounts for RANKL-Induced Tcirg1 Gene Expression During Osteoclastogenesis. Journal of Bone and Mineral Research, 2007, 22 (7), pp.975-983. ⟨10.1359/jbmr.070406⟩. ⟨hal-02109576⟩