A polymeric membrane permeabilizer displaying densely packed arrays of crown ether lateral substituents

Ming Liu , Anna Bertova (1) , Nicolas Illy (2) , Blandine Brissault (2) , Jacques Penelle (2) , Karol Ondrias (1) , Valessa Barbier (2)

1 Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
2 ICMPE - Institut de Chimie et des Matériaux Paris-Est

We report the design, synthesis and evaluation of a novel macromolecular membrane permeabilizer displaying geminally substituted crown-ethers (18-crown-6) on every third carbon alongside the backbone. The polymer has a rather high affinity with potassium as well as permeabilization properties towards K+, Na+ and Ca2+, including single-channel behavior.

Domaines: Polymères; Chimie de coordination; Biophysique

Ming Liu, Anna Bertova, Nicolas Illy, Blandine Brissault, Jacques Penelle, et al.. A polymeric membrane permeabilizer displaying densely packed arrays of crown ether lateral substituents. RSC Advances, 2012, 2 (23), pp.8606-8609. ⟨10.1039/c2ra20548c⟩. ⟨hal-02090277⟩