Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis

Abstract : Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.
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Julie Broggi, Nicolas Joubert, Vincent Aucagne, Sabine Berteina-Raboin, S. Diez-Gonzalez, et al.. Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis. Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2007, 26 (10-12), pp.1391-1394. ⟨10.1080/15257770701534139⟩. ⟨hal-02086003⟩



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