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Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the mouse epididymis

Abstract : Two glutathione peroxidase genes (gpx5 and gpx3) were found to be expressed in the mouse epididymis. Gpx5 was shown to be epididymis specific and restricted to the caput epididymidis, while gpx3 was found to be expressed in a wide array of tissues including the caput, corpus and cauda epididymides. Both single copy genes are regulated by androgens as well as being developmentally regulated during postnatal ontogenesis of the epididymis. In this report data collected to date concerning the mechanisms by which these genes are regulated in the mouse epididymis are summarized. The putative roles of these antioxidant enzymes in the sperm maturation process are discussed.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-02085759
Contributor : Vernet Patrick <>
Submitted on : Sunday, March 31, 2019 - 5:07:42 PM
Last modification on : Tuesday, March 17, 2020 - 2:19:55 AM

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  • HAL Id : hal-02085759, version 1

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V. Schwaab, Jean-Jacques Lareyre, Patrick Vernet, Eric Pons, Joëlle Faure, et al.. Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the mouse epididymis. Journal of Reproduction and Fertility, Portland Press, 1998, 53, pp.157-162. ⟨hal-02085759⟩

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