Superparamagnetic gadonanotubes are high-performance MRI contrast agents

Balaji Sitharaman , Kyle Kissell , Keith Hartman , Lesa Tran , Andrei Baikalov , Irene Rusakova , Yanyi Sun , Htet Khant , Steven Ludtke , Wah Chiu , Sabrina Laus , Éva Tóth (1) , Lothar Helm (2) , André Merbach , Lon Wilson

1 CBM - Centre de biophysique moléculaire
2 ISIC - Institut des sciences et d'ingénierie chimiques

We report the nanoscale loading and confinement of aquated Gd3+n-ion clusters within ultra-short single-walled carbon nanotubes (US-tubes); these Gd3+n@US-tube species are linear superparamagnetic molecular magnets with Magnetic Resonance Imaging (MRI) efficacies 40 to 90 times larger than any Gd3+-based contrast agent (CA) in current clinical use.

Domaines: Sciences du Vivant [q-bio]

Balaji Sitharaman, Kyle Kissell, Keith Hartman, Lesa Tran, Andrei Baikalov, et al.. Superparamagnetic gadonanotubes are high-performance MRI contrast agents. Chemical Communications, 2005, 31, pp.3915. ⟨10.1039/b504435a⟩. ⟨hal-02080330⟩