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Selective N-methylation of ethyl esters of 3-(1H-imidazol-4-yl)-2-propenoic acid

Abstract : Methods of selective methylation of the nitrogen atoms of the ethyl ester of 3‐(1H‐imidazol‐4‐yl)‐2‐propenoic acid are reported. The nitrogen atom α to the ethylenic chain was methylated after protection of the β nitrogen with a phenacyl group.
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https://hal.archives-ouvertes.fr/hal-02067313
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Hiba Mawlawi, Marie-Carmen Monje, Armand Lattes, M. Rivère. Selective N-methylation of ethyl esters of 3-(1H-imidazol-4-yl)-2-propenoic acid. Journal of Heterocyclic Chemistry, Wiley, 1992, 29 (6), pp.1621-1624. ⟨10.1002/jhet.5570290643⟩. ⟨hal-02067313⟩

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