Cobalt-Catalyzed Oxidative Homocoupling of Arylzinc Species

Yann Bourne-Branchu (1) , Aurélien Moncomble (1) , Martin Corpet (1) , Grégory Danoun (1) , Corinne Gosmini (1)

1 LCM - Laboratoire de chimie moléculaire

Dedicated to the memory of Professor Jean F. Normant; a brilliant scientist and a great person air or BQ r.t. CoBr 2 , cat. Zn Ar Br Ar ZnBr Ar Ar 18 examples 0-95% Ar = aryl or heteroaryl with FG = o-MeO, m-MeO, p-MeO, Me, NMe 2 , H, Cl, COMe, CN, CF 3 , CO 2 Et Reductive Process Oxidative Process Abstract A novel procedure for the synthesis of functionalized symmetrical biaryl compounds is described. The reaction proceeds via the oxidative homocoupling of arylzinc species formed by cobalt catalysis in the presence of air or p-benzoquinone depending on the nature of the functional group.

Mots clés: air; oxida-tive coupling; p-benzoquinone; homocoupling; arylzinc; cobalt; symmetrical biaryl

Domaines: Autre

Yann Bourne-Branchu, Aurélien Moncomble, Martin Corpet, Grégory Danoun, Corinne Gosmini. Cobalt-Catalyzed Oxidative Homocoupling of Arylzinc Species. Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (19), pp.3352-3356. ⟨10.1055/s-0035-1562488⟩. ⟨hal-02000533⟩