Hybrid metallic ion-exchanged waveguides for SPR biological sensing

Abstract : Glass substrates have been used for decades to create biosensors due to their biocompatibility, low thermal conductivity, and limited fluorescence. Among the different types of sensors, those based on surface plasmon resonance (SPR) allow exploitation of the sensing lightwave at the vicinity of the sensor surface where small entities such as DNA or proteins are located. In this paper, ion-exchanged waveguides and SPR are combined to create a multianalyte optical sensor integrated onto glass. First the principle of operation is introduced, then the theoretical analysis and design of the sensing element. Simulations have been carried out using the Aperiodic Fourier Modal Method (AFMM) and a custom software that handles ion-exchange index-profiles. Fabrication and characterization processes are also presented. Finally the first experimental spectra are displayed and discussed. The sensor presents a bulk sensibility of 5000nm/RIU.
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Sandie de Bonnault, Davide Bucci, P. .J. Zermatten, P. Charette, Jean-Emmanuel Broquin. Hybrid metallic ion-exchanged waveguides for SPR biological sensing. SPIE OPTO, Feb 2015, San Francisco, United States. pp.93650D, ⟨10.1117/12.2077648⟩. ⟨hal-01972286⟩

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