On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand

Abstract : We have designed a rigid photocleavable dianthracene-based ligand that reacts with ytterbium as coordination metal ion for the creation of a class of tridimensional light-degradable metal-organic framework (MOF). We demonstrated that we can obtain a high level of control on the disassembly of the MOF formed with this ligand which can be triggered either through light irradiation or temperature increase. The reversible 4pi-4pi photodimerization is the intrinsic chemical mechanism ruling the ligand and MOF cleavage. In the fields of biology and medicine, MOFs have sparked a strong interest as highly porous vehicles for drug release but have only been explored so far through the passive leakage of their payloads. The designed light-degradable MOFs can potentially overcome this limitation and serve as prototypes for drug delivery and corresponding therapeutic applications.
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https://hal.archives-ouvertes.fr/hal-01967507
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Submitted on : Monday, December 31, 2018 - 3:18:25 PM
Last modification on : Friday, April 26, 2019 - 9:06:02 AM

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Guillaume Collet, Timothée Lathion, Celine Besnard, Claude Piguet, Stéphane Petoud. On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand. Journal of the American Chemical Society, American Chemical Society, 2018, 140 (34), pp.10820-10828. ⟨hal-01967507⟩

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