Albumin infusion improves endothelial function in septic shock patients: a pilot study

Geoffroy Hariri (1) , Jérémie Joffre (1, 2) , Stephanie Deryckere (1) , Naïke Bigé (1) , Guillaume Dumas (1) , Jean-Luc Baudel (1) , Eric Maury (1, 2, 3) , Bertrand Guidet (1, 3, 2) , Hafid Ait-Oufella (4, 1, 2)

1 CHU Saint-Antoine [AP-HP]
2 SU FM - Sorbonne Université - Faculté de Médecine
3 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
4 PARCC - UMR-S U970 - Paris-Centre de Recherche Cardiovasculaire

Sepsis is a life-threatening condition in response to microbe injury, leading to tissue hypoperfusion, multiorgan failure and death. Human and experimental studies have shown that endothelial dysfunction is involved in microcirculatory blood flow impairment through several mechanisms including vasomotor tone dysregulation, activation of coagulation and glycocalyx damage [1]. Experimental studies suggested that human serum albumin (HSA) could have protective effects on endothelial cells [2], but such a hypothesis has never been directly tested in vivo. The aim of this study was to compare the effect of saline versus HSA bolus infusion on endothelial function in septic shock patients.

Domaines: Maladies infectieuses

Geoffroy Hariri, Jérémie Joffre, Stephanie Deryckere, Naïke Bigé, Guillaume Dumas, et al.. Albumin infusion improves endothelial function in septic shock patients: a pilot study. Intensive Care Medicine, 2018, 44 (5), pp.669-671. ⟨10.1007/s00134-018-5075-2⟩. ⟨hal-01959572⟩