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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

M. Philippe M. Neely Y. Bertrand N. Bleyzac Sylvain Goutelle 1
1 Evaluation et modélisation des effets thérapeutiques
Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]
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https://hal.archives-ouvertes.fr/hal-01943805
Contributor : Marie Pierre Armange <>
Submitted on : Tuesday, December 4, 2018 - 10:48:12 AM
Last modification on : Tuesday, July 20, 2021 - 5:20:07 PM

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M. Philippe, M. Neely, Y. Bertrand, N. Bleyzac, Sylvain Goutelle. A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics. Clinical Pharmacokinetics, Springer Verlag, 2017, 56, pp.435-447. ⟨10.1007/s40262-016-0448-6⟩. ⟨hal-01943805⟩

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