Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design

John Broad (1) , Damien Maurel (2, 3) , Victor W.S. Kung (1) , Gareth A. Hicks (4) , Michael Schemann (5) , Michael R. Barnes (6) , Terrence P. Kenakin (7) , Sébastien Granier (3, 2) , Gareth J. Sanger (1)

1 Blizard Institute - Barts & The London School of Medicine and Dentistry [London, UK]
2 IGF - Institut de Génomique Fonctionnelle
3 Departement /u661 : Pharmacologie Moleculaire
4 Tioga Pharmaceuticals [San Diego, CA, USA]
5 Human Biology [Freising-Weihenstephan, Germany]
6 NIHR Barts Biomedical Research Centre - The William Harvey Research Institute [London, UK]
7 Deparment of Pharmacology [Chapel Hill, NC, USA]

Domaines: Sciences du Vivant [q-bio]

John Broad, Damien Maurel, Victor W.S. Kung, Gareth A. Hicks, Michael Schemann, et al.. Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Scientific Reports, 2016, 6, pp.30797. ⟨10.1038/srep30797⟩. ⟨hal-01940963⟩