An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

K. S. S Mccommis , Wesley T Hodges , Daniel K Bricker , D. R. R Wisidagama , Vincent Compan (1) , M. S. S Remedi , C. S. S Thummel , B. N. N Finck

1 IGF - Institut de Génomique Fonctionnelle

Mots clés: GTT; glucose tolerance test; IMM; inner mitochondrial membrane; IPCs; Insulin-producing Cells; ITT; insulin tolerance test; MPC1 and MPC2; Mitochondrial Pyruvate Carrier 1 and 2; Pdx1; pancreatic and duodenal homeobox 1; Pyruvate; RESPYR; REporter Sensitive to PYRuvate; Stimulus-coupled secretion; b-Cell; GSIS; glucose-stimulated insulin secretion; Drosophila; Drosophila insulin-like peptide 2; DILP2; beta-Cell; Insulin; Mitochondria; Diabetes; OCR; oxygen consumption rates

Domaines: Sciences du Vivant [q-bio]

K. S. S Mccommis, Wesley T Hodges, Daniel K Bricker, D. R. R Wisidagama, Vincent Compan, et al.. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Molecular metabolism, 2016, 5 (8), pp.602--614. ⟨10.1016/j.molmet.2016.06.016⟩. ⟨hal-01936377⟩