trans- and cis-(Cl,Cl)-[RuII(FT)Cl2(NO)](PF6): promising candidates for NO release in the NIR region

J. Akl (1, 2) , Isabelle Sasaki (1) , P.G. Lacroix (1) , Vincent Hugues (3) , P. Vicendo (4, 5) , Mathilde Bocé (1, 6) , Sonia Mallet-Ladeira (7, 1) , M. Blanchard-Desce (3) , Isabelle Malfant (1, 2)

1 LCC - Laboratoire de chimie de coordination
2 UT3 - Université Toulouse III - Paul Sabatier
3 ISM - Institut des Sciences Moléculaires
4 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
5 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables
6 IPBS - Institut de pharmacologie et de biologie structurale
7 ICT - Institut de Chimie de Toulouse

cis- and trans-(Cl,Cl)-[RuII(FT)Cl2(NO)](PF6) complexes show efficient NO photodelivery upon two-photon excitation in the NIR region. Moreover, cytotoxicity and phototoxicity studies provide evidence that these complexes are promising candidates as photoactivatable molecular tools for resection of malignancies.

Domaines: Chimie de coordination

J. Akl, Isabelle Sasaki, P.G. Lacroix, Vincent Hugues, P. Vicendo, et al.. trans- and cis-(Cl,Cl)-[RuII(FT)Cl2(NO)](PF6): promising candidates for NO release in the NIR region. Photochemical & Photobiological Sciences , 2016, 15 (12), pp.1484-1491. ⟨10.1039/C6PP00181E⟩. ⟨hal-01935119⟩