Metabolic profiling identification of metabolites formed in Mediterranean mussels ( Mytilus galloprovincialis ) after diclofenac exposure - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Science of the Total Environment Année : 2017

Metabolic profiling identification of metabolites formed in Mediterranean mussels ( Mytilus galloprovincialis ) after diclofenac exposure

Lauren Arpin-Pont
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Elena Gomez
Frederique Courant

Résumé

Despite the growing concern on the presence of pharmaceutically active compounds in the environment, few studies have been conducted on their metabolism in marine organisms. In this study, a non-targeted strategy based on the generation of chemical profiles generated by liquid chromatography combined with high resolution mass spectrometry was used to highlight metabolite production by the Mediterranean mussel (Mytilus galloprovincialis) after diclofenac exposure. This method allowed revealing the production of 13 metabolites in mussel tissues. Three of them were phase I metabolites, including 4′-hydroxy-diclofenac and 5-hydroxy-diclofenac. The remaining 10 were phase II metabolites, including sulfate and amino acids conjugates. Among all of the metabolites highlighted, 5 were reported for the first time in an aquatic organism exposed to diclofenac.
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Dates et versions

hal-01928465 , version 1 (20-11-2018)

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Citer

Benilde Bonnefille, Lauren Arpin-Pont, Elena Gomez, Hélène Fenet, Frederique Courant. Metabolic profiling identification of metabolites formed in Mediterranean mussels ( Mytilus galloprovincialis ) after diclofenac exposure. Science of the Total Environment, 2017, 583, pp.257 - 268. ⟨10.1016/j.scitotenv.2017.01.063⟩. ⟨hal-01928465⟩
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