Post-testicular sperm maturation, infertility and hypercholesterolaemia

Joël J. Drevet (1) , Xavier Pollet-Villard (2) , Rachel Levy (2) , Fabrice Saez (1) , Marjorie Whitfield (1)

1 GReD - Génétique, Reproduction et Développement
2 Hôpital Jean Verdier [AP-HP]

Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia) affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa.

Mots clés: cholesterol; dyslipidemia; epididymis; fertility; spermatozoa; PROTEIN-TYROSINE PHOSPHORYLATION; HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; CHOLESTEROL HOMEOSTASIS; EPIDIDYMAL MATURATION; MALE-FERTILITY; MOUSE SPERMATOZOA

Mots clés: posttesticular maturation; LIVER-X-RECEPTORS; METABOLIC SYNDROME; MAMMALIAN SPERMATOZOA; APOLIPOPROTEIN-B

Domaines: Reproduction sexuée; Gamétogenèse; Immunité adaptative

Joël J. Drevet, Xavier Pollet-Villard, Rachel Levy, Fabrice Saez, Marjorie Whitfield. Post-testicular sperm maturation, infertility and hypercholesterolaemia. Asian Journal of Andrology, 2015, 17 (5), pp.742 - 748. ⟨10.4103/1008-682X.155536⟩. ⟨hal-01920008⟩