Real-time endoscopic optical properties imaging.

Joseph Angelo (1, 2) , Martijn van de Giessen (3) , Sylvain Gioux (4, 5)

1 Department of Medicine [Boston, MA, USA]
2 Department of Biomedical Engineering [Boston]
3 Department of Radiology [Leiden, The Netherlands]
4 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
5 Department of Surgery [Boston, MA, USA]

With almost 50% of all surgeries in the U.S. being performed as minimally invasive procedures, there is a need to develop quantitative endoscopic imaging techniques to aid surgical guidance. Recent developments in widefield optical imaging make endoscopic implementations of real-time measurement possible. In this work, we introduce a proof-of concept endoscopic implementation of a functional widefield imaging technique called 3D single snapshot of optical properties (3D-SSOP) that provides quantitative maps of absorption and reduced scattering optical properties as well as surface topography with simple instrumentation added to a commercial endoscope. The system’s precision and accuracy is validated using tissue-mimicking phantoms, showing a max error of 0.004 mm−1, 0.05 mm−1, and 1.1 mm for absorption, reduced scattering, and sample topography, respectively. This study further demonstrates video acquisition of a moving phantom and an in vivo sample with a framerate of approximately 11 frames per second.

Keywords: Imaging systems; Endoscopic imaging; Medical optics and biotechnology

Domains: Optics / Photonic; Bioengineering

Joseph Angelo, Martijn van de Giessen, Sylvain Gioux. Real-time endoscopic optical properties imaging.. Biomedical optics express, 2017, 8 (11), pp.5113-5126. ⟨10.1364/BOE.8.005113⟩. ⟨hal-01878616⟩