Fluorescent nanoparticles for the guided surgery of ovarian peritoneal carcinomatosis

Tristan Mangeolle (1, 2) , Ilya Yakavets (2, 1, 3) , Sophie Simon Marchal (1, 2) , Manon Debayle (4) , Thomas Pons (4) , Lina Bezdetnaya (2, 1) , Frédéric Marchal (2, 1)

1 CRAN - Centre de Recherche en Automatique de Nancy
2 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
3 Belarusian State University
4 LPEM - Laboratoire de Physique et d'Etude des Matériaux (UMR 8213)

Complete surgical resection is the ideal cure for ovarian peritoneal carcinomatosis, but remains challenging. Fluorescent guided surgery can be a promising approach for precise cytoreduction when appropriate fluorophore is used. In the presence paper, we review already developed near- and short-wave infrared fluorescent nanoparticles, which are currently under investigation for peritoneal carcinomatosis fluorescence imaging. We also highlight the main ways to improve the safety of nanoparticles, for fulfilling prerequisites of clinical application.

Domaines: Sciences du Vivant [q-bio]

Tristan Mangeolle, Ilya Yakavets, Sophie Simon Marchal, Manon Debayle, Thomas Pons, et al.. Fluorescent nanoparticles for the guided surgery of ovarian peritoneal carcinomatosis. Nanomaterials, 2018, 8 (8), pp.572. ⟨10.3390/nano8080572⟩. ⟨hal-01860308⟩