Twisted Charge-Transfer Antennae for Ultra-Bright Terbium(III) and Dysprosium(III) Bioprobes

Anh Thy Bui (1) , Amandine Roux (1) , Alexei Grichine (2) , Alain Duperray (2, 3) , Chantal Andraud (1) , Olivier Maury (1)

1 LC - Laboratoire de Chimie - UMR5182
2 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
3 INSERM U1209, équipe Patrice Marche (Immunologie Analytique des Pathologies Chroniques)

The design of original twisted charge transfer antennae in which a non-planar geometry is enforced thanks to one or two bulky ortho-Me substituents allows us to prepare the corresponding ultra-bright TbIII and DyIII bioprobes. The brightness of the TbIII derivative compares well with that of the benchmark Tb-Lumi4 complex. The first bio-imaging experiments with a DyIII luminescent bioprobe are also reported.

Domaines: Catalyse; Matériaux; Chimie organique; Chimie inorganique

Anh Thy Bui, Amandine Roux, Alexei Grichine, Alain Duperray, Chantal Andraud, et al.. Twisted Charge-Transfer Antennae for Ultra-Bright Terbium(III) and Dysprosium(III) Bioprobes. Chemistry - A European Journal, 2018, 24 (14), pp.3408 - 3412. ⟨10.1002/chem.201705933⟩. ⟨hal-01848916⟩