A three year follow-up study of gadolinium enhanced and non-enhanced regions in multiple sclerosis lesions using a multi-compartment T2 relaxometry model.

Sudhanya Chatterjee 1 Olivier Commowick 1 Onur Afacan 2 Benoit Combes 1 Simon Warfield 2 Christian Barillot 1
1 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U1228, Inria Rennes – Bretagne Atlantique , IRISA_D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Demyelination, axonal damage and inflammation are critical indicators of the onset and progress of neurodegenerative diseases such as multiple sclerosis (MS) in patients. Due to physical limitations of imaging such as acquisition time and imaging resolution, a voxel in a MR image is heterogeneous in terms of tissue microstructure such as myelin, axons, intra and extra cellular fluids and free water. We present a multi-compartment tissue model which estimates the water fraction (WF) of tissues with short, medium and high T 2 relaxation times in a T 2 relaxometry MRI voxel. The proposed method is validated on test-retest data of healthy controls. This model was then used to study longitudinal trends of the tissue microstructures for two sub-regions of the lesions: gadolinium enhanced (E+) and non-enhanced (L−) regions of MS lesions in 10 MS patients over a period of three years. The water fraction values in E+ and L− regions were found to be significantly different (p < 0.05) over the period of first three months. The results of this study also showed that the estimates of the proposed T 2 relaxometry model on brain tissue microstructures have potential to distinguish between regions undergoing active blood brain barrier breakdown from the other regions of the lesion.
Type de document :
Pré-publication, Document de travail
2018
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01837974
Contributeur : Sudhanya Chatterjee <>
Soumis le : vendredi 13 juillet 2018 - 08:58:19
Dernière modification le : mardi 17 juillet 2018 - 01:09:23
Document(s) archivé(s) le : lundi 15 octobre 2018 - 19:30:11

Fichier

bioArxiv_preprint_three_year_f...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Sudhanya Chatterjee, Olivier Commowick, Onur Afacan, Benoit Combes, Simon Warfield, et al.. A three year follow-up study of gadolinium enhanced and non-enhanced regions in multiple sclerosis lesions using a multi-compartment T2 relaxometry model.. 2018. 〈hal-01837974〉

Partager

Métriques

Consultations de la notice

209

Téléchargements de fichiers

20