Study of Intrinsic Cardiac Dysfunction in Septic Shock Conditions by Isolated Working Heart: A Primary Approach before New Therapeutic Proposals?

Marine Ferron (1) , Valentine Prat (1) , D. Roul (1) , Julien Cadiet (1) , Chantal Gauthier (1) , Bertrand Rozec (2, 1) , Benjamin Lauzier (1)

1 ITX - ITX - unité de recherche de l'institut du thorax
2 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital

Septic shock is an inflammatory response to an infection leading to cardiovascular dysfunction. Today, only few studies have evaluated whether cardiac dysfunction in septic shock is due to load modifications, neuroendocrine influence or intrinsic cardiac alterations. The isolated working heart approach allows measurement of cardiac function under controlled conditions. Our study demonstrated for the first time that in septic shock rat, alteration of cardiac function is characterized by both systolic and diastolic dysfunctions beside load conditions. This observation might help to apprehend the particular dysfunction associated with sepsis.

Domaines: Sciences du Vivant [q-bio]

Marine Ferron, Valentine Prat, D. Roul, Julien Cadiet, Chantal Gauthier, et al.. Study of Intrinsic Cardiac Dysfunction in Septic Shock Conditions by Isolated Working Heart: A Primary Approach before New Therapeutic Proposals?. SM Emergency Medicine and Critical Care , 2017, 1 (3). ⟨hal-01832937⟩