Brugada syndrome: Diagnosis, risk stratification and management

Jean-Baptiste Gourraud (1) , Julien Barc (1) , Aurélie Thollet (1) , Hervé Le Marec (1) , Vincent Probst (1)

1 ITX - ITX - unité de recherche de l'institut du thorax

Brugada syndrome is a rare inherited arrhythmia syndrome leading to an increased risk of sudden cardiac death, despite a structurally normal heart. Diagnosis is based on a specific electrocardiogram pattern, observed either spontaneously or during a sodium channel blocker test. Among affected patients, risk stratification remains a challenge, despite recent insights from large population cohorts. As implantable cardiac defibrillators - the main therapy in Brugada syndrome - are associated with a high rate of complications in this population, the main challenge is risk stratification of patients with Brugada syndrome. Aside from the two main predictors of arrhythmia (symptoms and spontaneous electrocardiogram pattern), many risk factors have been recently suggested for stratifying risk of sudden cardiac death in Brugada syndrome. We have reviewed these data and discuss current guidelines in light of recent progress in this complex field.

Mots clés: Brugada syndrome; Prognosis; Diagnosis; Sudden cardiac death; Risk stratification

Domaines: Sciences du Vivant [q-bio]

Jean-Baptiste Gourraud, Julien Barc, Aurélie Thollet, Hervé Le Marec, Vincent Probst. Brugada syndrome: Diagnosis, risk stratification and management. Archives of cardiovascular diseases, 2017, Equipe I Equipe IIa, 110 (3), pp.188--195. ⟨10.1016/j.acvd.2016.09.009⟩. ⟨hal-01832150⟩