Hepatitis A: an epidemiological survey in blood donors, France 2015 to 2017

Pierre Gallian (1, 2) , Valérie Barlet (3) , Lina Mouna (4, 5) , Sylvie Gross (6) , Sophie Lecam (7) , Céline Ricard (8) , Françoise Wind (9) , Elodie Pouchol (6) , Cécile Fabra (1) , Benoit Flan (10) , Catherine Visse (10) , Rachid Djoudi (6) , Elisabeth Couturier (11) , Henriette de Valk (11) , Pierre Tiberghien (12) , Anne-Marie Roque-Afonso (13)

1 EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée
2 UVE - Unité des Virus Emergents
3 EFS - Etablissement français du sang - Auvergne-Rhône-Alpes
4 I2BC - Institut de Biologie Intégrative de la Cellule
5 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
6 EFS - Etablissement Français du Sang [La Plaine Saint-Denis]
7 Etablissement Français du Sang [Nantes]
8 EFS Hauts-de-France - Normandie - Etablissement Français du Sang Hauts-de-France - Normandie
9 EFS Occitanie - Etablissement Français du Sang [Occitanie]
10 LFB Biomédicaments
11 INVS - Institut de Veille Sanitaire
12 RIGHT - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
13 Pathogénèse et traitement de l'hépatite fulminante et du cancer du foie

Since mid-2016, hepatitis A virus (HAV) outbreaks, involving predominantly men who have sex with men (MSM), have affected countries in Europe and overseas. In France, HAV screening of blood donations in 2017 revealed a HAV-RNA prevalence ca fivefold higher than during 2015-16 (4.42/106 vs 0.86/106; p = 0.0005). In 2017, despite a higher male-to-female ratio (5.5 vs 0.7) and the identification of MSM-associated outbreak strains, only one of 11 infected male donors self-reported being a MSM. Since mid-2016, outbreaks involving mainly men who have sex with men (MSM) have been reported in European countries and overseas [1-6]. The outbreaks were associated with three genotype IA hepatitis A virus (HAV) strains: VDR_521_2016, RIVM_HAV16-090 and V16-25801. In this study, we report epidemiological and clinical findings pertaining to HAV infected blood donors before and during the recent outbreak in France.

Mots clés: 2 Unité des Virus Emergents (UVE: Aix-Marseille Univ -IRD 190 -Inserm 1207 -IHU Méditerranée Infection); Marseille; France 3 Etablissement Français du Sang Auvergne Rhône Alpes; Beynost; France 4 AP-HP; Hôpital Paul Brousse; Virologie; CNR des Virus des hépatites à transmission entérique; INSERM U1993; Villejuif; France 5 Etablissement Français du Sang; Saint Denis-La

Domaines: Sciences du Vivant [q-bio]

Pierre Gallian, Valérie Barlet, Lina Mouna, Sylvie Gross, Sophie Lecam, et al.. Hepatitis A: an epidemiological survey in blood donors, France 2015 to 2017. Eurosurveillance, 2018, 23 (21), ⟨10.2807/1560-7917.ES.2018.23.21.1800237⟩. ⟨hal-01826305⟩