Higher third-generation cephalosporin prescription proportion is associated with lower probability of reducing carbapenem use: a nationwide retrospective study

Allison Muller (1, 2) , Xavier Bertrand (1, 2) , Anne-Marie Rogues (3) , Muriel Péfau (4) , Serge Alfandari (5) , Rémy Gauzit (6) , Catherine Dumartin (7) , Houssein Gbaguidi-Haore (2, 1)

1 LCE - Laboratoire Chrono-environnement (UMR 6249)
2 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
3 Hôpital Pellegrin, CHU de Bordeaux
4 CHU Bordeaux
5 Service des maladies infectieuses
6 Unité de Réanimation
7 BPH - Bordeaux population health

The ongoing extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) pandemic has led to an increasing carbapenem use, requiring release of guidelines for carbapenem usage in France in late 2010. We sought to determine factors associated with changes in carbapenem use in intensive care units (ICUs), medical and surgical wards between 2009 and 2013.

Mots clés: Antibiotic stewardship; Antibiotic use; Carbapenem; ESBL; Multidrug-resistant bacteria

Domaines: Microbiologie et Parasitologie

Allison Muller, Xavier Bertrand, Anne-Marie Rogues, Muriel Péfau, Serge Alfandari, et al.. Higher third-generation cephalosporin prescription proportion is associated with lower probability of reducing carbapenem use: a nationwide retrospective study. Antimicrobial Resistance and Infection Control, 2018, 7 (1), pp.11. ⟨10.1186/s13756-018-0302-8⟩. ⟨hal-01812646⟩