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Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction – Formulation and preliminary results

Abstract : We propose a multiscale model of cardiac contraction in which the molecular motors at the origin of the contractile process are considered as multistable mechanical entities endowed with internal degrees of freedom of both mechanical and chemical nature. This model provides a thermodynamical basis for modeling the complex interplay of chemical and mechanical phenomena at the sub-cellular level. Important motivations for this work include the ability to represent the experimentally observed physiological characteristics of the contractile apparatus such as (i) the passive quick force recovery mechanism, (ii) the relation between the contraction velocity and the applied force and (iii) the so called Lymn-Taylor cycle describing the metabolism.
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https://hal.archives-ouvertes.fr/hal-01802124
Contributor : Matthieu Caruel <>
Submitted on : Tuesday, May 29, 2018 - 8:56:45 AM
Last modification on : Friday, April 30, 2021 - 9:53:15 AM
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  • HAL Id : hal-01802124, version 1

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M. Caruel, P Moireau, D Chapelle. Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction – Formulation and preliminary results. 22e congrès Français de Mécanique, Aug 2015, Lyon, France. ⟨hal-01802124⟩

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