Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation

Stefan Matecki (1, 2) , Haikel Dridi (1) , Boris Jung (1, 2) , Nathalie Saint (1) , Steven Reiken (3, 4) , Valérie Scheuermann (1) , Ségolène Mrozek (2) , Gaetano Santulli (5, 4) , Alisa Umanskaya (4) , Basil Petrof (6) , Samir Jaber (2) , Andrew Marks (4) , Alain Lacampagne (1)

1 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 Department of Physiology & Cellular Biophysics
4 Columbia University [New York]
5 CUIMC - Columbia University Irving Medical Center
6 McGill University = Université McGill [Montréal, Canada]

Mots clés: skeletal muscle; excitation–contraction coupling; calcium; beta adrenergic signaling; VIDD

Domaines: Sciences du Vivant [q-bio]

Stefan Matecki, Haikel Dridi, Boris Jung, Nathalie Saint, Steven Reiken, et al.. Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (32), pp.9069 - 9074. ⟨10.1073/pnas.1609707113⟩. ⟨hal-01800610⟩