Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?

Stefan Matecki (1, 2) , Lisa Kent (3, 4) , Kris de Boeck (5) , Muriel Le Bourgeois (6) , Stefan Zielen (7) , Cesare Braggion (8) , H.G.M. Arets (9) , Judy Bradley (10) , Stephanie Davis (11) , Isabelle Sermet (12, 6) , Philippe Reix (13)

1 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 Health and Rehabilitation Sciences Research Institute
4 University of Ulster, Newtownabbey,
5 University of Leuven Medical School, University Hospitals KULeuven
6 Hôpital Necker - Enfants Malades [AP-HP]
7 J.W. Goethe Universität, Institut für Geowissenschaften, Altenhöferallee 1, D-60438 Frankfurt am Main, Germany
8 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
9 University Medical Center [Utrecht]
10 Belfast Health and Social Care Trust
11 Cystic Fibrosis Pediatric Centre, Indianapolis
12 UMR_S 845 - Centre de recherche Croissance et signalisation
13 UCBL - Université Claude Bernard Lyon 1

The European Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN) has established a Standardization Committee to undertake a rigorous evaluation of promising outcome measures with regard to use in multicentre clinical trials in cystic fibrosis (CF). The aim of this article is to present a review of literature on clinimetric properties of the infant raised-volume rapid thoracic compression (RVRTC) technique in the context of CF, to summarise the consensus amongst the group on feasibility and answer key questions regarding the promotion of this technique to surrogate endpoint status.

Mots clés: Clinical trials; Clinimetric properties; Cystic fibrosis; Infant pulmonary function; Raised volume rapid thoracic compression; Surrogate outcome

Domaines: Sciences du Vivant [q-bio]

Stefan Matecki, Lisa Kent, Kris de Boeck, Muriel Le Bourgeois, Stefan Zielen, et al.. Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?. Journal of Cystic Fibrosis, 2016, 15 (1), pp.10 - 20. ⟨10.1016/j.jcf.2015.03.015⟩. ⟨hal-01800607⟩