Multiple Structures Disclose the Secretins' Secrets

Alain Filloux (1) , Romé Voulhoux (2)

1 Department of Life Sciences
2 LISM - Laboratoire d'ingénierie des systèmes macromoléculaires

Bacterial secretins are outer membrane proteins that provide a path for secreted proteins to access the cell exterior/surface. They are one of the core components of secretion machines and are found in type II and type III secretion systems (T2SS and T3SS, respectively). The secretins comprise giant ring-shaped homo-oligomers whose precise atomic organization was only recently deciphered thanks to spectacular developments in cryo-electron microscopy (cryo-EM) imaging techniques .

Mots clés: T2SS; secretin; GspD

Domaines: Bactériologie

Alain Filloux, Romé Voulhoux. Multiple Structures Disclose the Secretins' Secrets. Journal of Bacteriology, 2018, 200 (5), ⟨10.1128/JB.00702-17⟩. ⟨hal-01791779⟩