Antigen 5-spiked Vespula and Polistes venom extracts for Vespid allergy diagnostics: A French multicenter study

Claude Lambert (1) , Joelle Birnbaum (2) , Charles Dzviga (1) , Nicolas Hutt (3) , Pol-André Apoil (4) , Francoise Bienvenu (5) , Martine Drouet (6) , Celine Beauvillain (7) , Severine Brabant (8) , Laurence Guilloux (9) , Delphine Mariotte (10) , Francois Lavaud (11) , Pascale Nicaise-Roland (12) , Thierry Tabary (11) , Anne Sarrat (13) , Joana Vitte (14)

1 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
2 Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM]
3 Nouvel Hôpital Civil de Strasbourg
4 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
5 Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]
6 CHU Angers - Centre Hospitalier Universitaire d'Angers
7 CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
8 Institut d'Immunologie [CHRU Lille]
9 Eurofins Biomnis
10 Laboratoire d'Immunologie [CHU Caen]
11 CHU Reims - Hôpital universitaire Robert Debré [Reims]
12 Unité Fonctionnelles d′Immunologie [CHU Bichat]
13 Service d'immunologie et d'immunogénétique [Bordeaux]
14 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection

Vespula and Polistes spp venom extracts (VEs) for ImmunoCAP (Thermo Fisher Scientific, Uppsala, Sweden) platforms have been spiked, that is, enriched, with group 5 allergens since 2012. Limited information was available from the manufacturer, but small cohorts have reported altered performance for in vitro diagnostics.1,2 Herein we present the results of a French multicenter study on antigen 5–spiked Vespula and Polistes VEs compared with nonspiked VEs

Domaines: Maladies infectieuses

Claude Lambert, Joelle Birnbaum, Charles Dzviga, Nicolas Hutt, Pol-André Apoil, et al.. Antigen 5-spiked Vespula and Polistes venom extracts for Vespid allergy diagnostics: A French multicenter study. Annals of Allergy, Asthma and Immunology, 2018, 120 (4), pp.435-437. ⟨10.1016/j.anai.2018.01.011⟩. ⟨hal-01791587⟩