Validation of inhomogeneous Magnetization Transfer (ihMT) as a myelin biomarker

Valentin H Prevost , Olivier M Girard , Myriam Cayre , Gopal Varma , Samira Mchinda , Jean-Philippe Ranjeva (1) , Jean Pelletier (1) , Pascale Durbec (2) , David C Alsop , Guillaume Duhamel (1)

1 CRMBM - Centre de résonance magnétique biologique et médicale
2 IBDM - Institut de Biologie du Développement de Marseille

The ihMT (inhomogeneous Magnetization transfer) signal qualitatively demonstrates sensitivity for myelinated structures. However, image intensity and contrast vary with the saturation parameters, further questioning the specificity of ihM for myelin. This study validated ihMT as a myelin biomarker by demonstrating for various ihMT sequences, linear relationships between ihMT signal and intensity of fluorescence microscopy (a quantitative myelin specific histology technique) collected in plp-GFP mouse brain.

Domaines: Imagerie; Imagerie médicale

Valentin H Prevost, Olivier M Girard, Myriam Cayre, Gopal Varma, Samira Mchinda, et al.. Validation of inhomogeneous Magnetization Transfer (ihMT) as a myelin biomarker. Proc. Intl. Soc. Mag. Reson. Med. 25, 2017, Unknown, Unknown Region. pp.4549. ⟨hal-01784676⟩