Combined maximum-quantum and DOSY 3D experiments provide enhanced resolution for small molecules in mixtures
Résumé
We illustrate here as the combination of high-order maximum-quantum (MaxQ) and Diffusion-Ordered SpectroscopY (DOSY) NMR experiments in a 3D layout allows superior resolution for crowded NMR spectra. Non-uniform sampling (NUS) allows compressing the experimental time effectively to reasonable durations. Because diffusion effects were encoded within multiple-quantum co-herences, increased sensitivity to magnetic field gradients is observed, requiring compensation for convection effects. The experiment was demonstrated on the spectra of a mix of small polyaromatic molecules. Specifically, in the case analyzed, the experiment provided an extreme simplification through the MaxQDOSY-MaxQ projection plane that presents one peak per molecule.
Domaines
Chimie analytique
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Reddy_et_al-2016-Magnetic_Resonance_in_Chemistry.pdf (939.44 Ko)
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