Th-17 response and antimicrobial peptide expression are uniformly expressed in gastric mucosa of Helicobacter pylori -infected patients independently of their clinical outcomes

Julie Cremniter (1) , Charles Bodet (1) , David Tougeron (1) , Xavier Dray (2) , Joëlle Guilhot (3) , Jean-François Jégou (1) , Franck Morel (1) , Jean-Claude Lecron (1) , Christine Silvain (4, 1) , Christophe Burucoa (5, 1)

1 LITEC [Poitiers] - Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331]
2 ASTRE [Cergy-Pontoise]
3 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
4 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
5 Laboratoire de Bactériologie, CHU de Poitiers

The pathological determinism of H. pylori infection is explained by complex interplay between bacterial virulence and host inflammatory response. In a large prospective multicenter clinical study, Th17 response, expression of antimicrobial peptides (AMP s), cagA and vacA status, and bacterial density were investigated in the gastric mucosa of H. pylori ‐infected patients.

Domains: Immunology; Microbiology and Parasitology

Julie Cremniter, Charles Bodet, David Tougeron, Xavier Dray, Joëlle Guilhot, et al.. Th-17 response and antimicrobial peptide expression are uniformly expressed in gastric mucosa of Helicobacter pylori -infected patients independently of their clinical outcomes. Helicobacter, 2018, 23, pp.e12479. ⟨10.1111/hel.12479⟩. ⟨hal-01780541⟩