An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

Bartolome Celli , Marc Decramer , Jadwiga Wedzicha , Kevin Wilson , Alvar Agustí , Gerard Criner , William Macnee (1) , Barry Make , Stephen Rennard , Robert Stockley , Claus Vogelmeier , Antonio Anzueto , David Au , Peter Barnes , Pierre-Régis Burgel (2) , Peter Calverley , Ciro Casanova , Enrico Clini , Christopher Cooper , Harvey Coxson , Daniel Dusser (2) , Leonardo Fabbri , Bonnie Fahy , Gary Ferguson , Andrew Fisher , Monica Fletcher (3) , Maurice Hayot (4, 5) , John Hurst , Paul Jones , Donald Mahler , François Maltais (6) , David Mannino , Fernando Martinez , Marc Miravitlles , Paula Meek , Alberto Papi (7) , Klaus F. Rabe (8) , Nicolas Roche (9) , Frank Sciurba , Sanjay Sethi , Nikos Siafakas , Don Sin , Joan Soriano , James Stoller , Donald Tashkin , Thierry Troosters , Geert Verleden , John Verschakelen , Jorgen Vestbo (10) , John W. Walsh , George Washko (11) , Robert A. Wise , Emiel F.M. Wouters (12) , Richard Zuwallack

1 Queen's Medical Researche Institute
2 Service de pneumologie [CHU Cochin]
3 Education for Health
4 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
6 IUCPQ - Institut Universitaire de Cardiologie et de Pneumologie de Québec
7 UniFE - Università degli Studi di Ferrara = University of Ferrara
8 Department of Pulmonary Medicine
9 Service de Pneumologie et Soins Intensifs Respiratoires
10 Wythenshawe Hospital
11 Brigham and Women's Hospital [Boston]
12 Maastricht University [Maastricht]

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) research statement is to describe evidence related to diagnosis, assessment and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified. Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ ERS research statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centred outcomes. @ERSpublications ATS/ERS statement: which types of research will have the greatest future impact on patient-centred outcomes in COPD? http://ow.ly/I54Hb

Domaines: Pneumologie et système respiratoire

Bartolome Celli, Marc Decramer, Jadwiga Wedzicha, Kevin Wilson, Alvar Agustí, et al.. An official American Thoracic Society/European Respiratory Society statement: research questions in COPD. European Respiratory Journal, 2015, 45 (4), pp.879-905. ⟨10.1183/09031936.00009015⟩. ⟨hal-01756210v2⟩