Conversion of pericytes to neurons: a new guest at the reprogramming convention

Abstract : Reprogramming strategies allow for the generation of virtually any cell type of the human body, which could be useful for cell-based therapy. Among the different reprogramming technologies available, direct lineage conversion offers the possibility to change the phenotype of a cell type to another one without pushing cells backwards to a plastic/proliferative stage. This approach has raised the possibility to apply a similar process in vivo in order to compensate for functional cell loss. Historically, the cerebral tissue is a prime choice for developing cell-based treatments. As local pericyte accumulation is observed after central nervous system injury, it can be reasoned that this cell type might be a good candidate for the conversion into new neurons in vivo. In this article, and by focusing on recent observations from Karow and colleagues demonstrating the possibility to convert human brain-derived pericytes into functional neurons, we present a brief overview of the state of the art and attempt to offer perspective as to how these interesting laboratory findings could be translated in the clinic.
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Submitted on : Friday, March 16, 2018 - 4:38:08 PM
Last modification on : Tuesday, April 10, 2018 - 9:24:28 AM

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Emmanuel Nivet, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte. Conversion of pericytes to neurons: a new guest at the reprogramming convention. Stem Cell Research and Therapy, BioMed Central, 2013, 4 (1), pp.2. ⟨10.1186/scrt150⟩. ⟨hal-01736196⟩

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