Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia

Guillaume Gauchotte (1, 2) , Sébastien Hergalant (1) , Charlène Vigouroux (2) , Matthieu Casse (1, 2) , Rémi Houlgatte (1) , Tony Kaoma (3) , Déborah Helle (1) , Lydia Brochin (2) , Fabien Rech (4, 5) , Matthieu Peyre (6, 7) , François Labrousse (8) , Laurent Vallar (3) , Jean-Louis Guéant (1, 9) , Jean-Michel Vignaud (1, 10, 2) , Shyue-Fang Battaglia-Hsu (1, 9)

1 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
2 Service de Pathologie [CHRU Nancy]
3 LIH - Luxembourg Institute of Health
4 Service de Neurochirurgie [CHRU Nancy]
5 INM - Institut des Neurosciences de Montpellier
6 CHU Pitié-Salpêtrière [AP-HP]
7 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
8 Service d'Anatomie Pathologique [CHU Limoges]
9 M2TP, Division of Biochemistry and Molecular Biology [CHRU Nancy]
10 CRB Nancy - Centre de Ressources Biologiques - [Nancy]

Domaines: Sciences du Vivant [q-bio]; Cancer

Guillaume Gauchotte, Sébastien Hergalant, Charlène Vigouroux, Matthieu Casse, Rémi Houlgatte, et al.. Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia. The Journal of pathology and bacteriology, 2017, 242 (4), pp.421 - 434. ⟨10.1002/path.4916⟩. ⟨hal-01718786⟩