Improved synthesis of 6-[(ethylthio)methyl]-1H-indazole

Agnès M. Sirven (1) , Roman Stefak (1) , Gwénaël Rapenne (1)

1 CEMES - Centre d'élaboration de matériaux et d'études structurales

In the improved synthesis of 6-[(ethylthio)methyl]-1H-indazole (5), the mesylate intermediate is replaced by the bromide derivative, which increases the overall yield (six steps) by a factor of 3.

Domaines: Physique [physics]

Agnès M. Sirven, Roman Stefak, Gwénaël Rapenne. Improved synthesis of 6-[(ethylthio)methyl]-1H-indazole. Heterocyclic communications, 2015, 21 (1), pp.5-8. ⟨10.1515/hc-2014-0180⟩. ⟨hal-01717638⟩