Divergent Cortical Generators of MEG and EEG during Human Sleep Spindles Suggested by Distributed Source Modeling

Nima Dehghani (1, 2) , Sydney S Cash (3) , Chih C Chen (4) , Donald J Hagler (5) , Mingxiong Huang , Anders M Dale (5) , Eric Halgren (5)

1 UNIC - Unité de Neurosciences Information et Complexité [Gif sur Yvette]
2 INAF - Institut de Neurobiologie Alfred Fessard
3 Department Neurology, Department of Neurosurgery, MGH
4 Department of Neurology, National Taiwan University Hospital
5 UCSD - Multimodal Imaging Laboratory, Department Radiology and Neurosciences

Sleep spindles are approximately 1-second bursts of 10-15 Hz activity, occurring during normal stage 2 sleep. In animals, sleep spindles can be synchronous across multiple cortical and thalamic locations, suggesting a distributed stable phase-locked generating system. The high synchrony of spindles across scalp EEG sites suggests that this may also be true in humans. However, prior MEG studies suggest multiple and varying generators.

Domaines: Neurobiologie; Psychologie et comportements; Sciences cognitives

Nima Dehghani, Sydney S Cash, Chih C Chen, Donald J Hagler, Mingxiong Huang, et al.. Divergent Cortical Generators of MEG and EEG during Human Sleep Spindles Suggested by Distributed Source Modeling. PLoS ONE, 2010, 5 (7), pp.e11454. ⟨10.1371/journal.pone.0011454⟩. ⟨hal-01685268⟩