Prospective, multicenter French study evaluating the clinical impact of the Breast Cancer Intrinsic Subtype-Prosigna® Test in the management of early-stage breast cancers

Abstract : The Prosigna® breast cancer prognostic gene signature assay identifies a gene-expression profile that permits the classification of tumors into subtypes and gives a score for the risk of recurrence (ROR) at 10 years. The primary objective of this multicenter study was to evaluate the impact of Prosigna's assay information on physicians' adjuvant treatment decisions in patients with early-stage breast cancer. Secondary objectives were to assess confidence of practitioners in their therapeutic recommendations before and after the added information provided by the Prosigna assay; and to evaluate the emotional state of patients before and after the Prosigna test results.
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https://hal.archives-ouvertes.fr/hal-01675231
Contributor : Frédérique Penault-Llorca <>
Submitted on : Thursday, January 4, 2018 - 11:20:14 AM
Last modification on : Tuesday, May 28, 2019 - 1:46:35 AM

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Delphine Hequet, Céline Callens, David Gentien, Benoit Albaud, Marie-Ange Mouret-Reynier, et al.. Prospective, multicenter French study evaluating the clinical impact of the Breast Cancer Intrinsic Subtype-Prosigna® Test in the management of early-stage breast cancers. PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0185753. ⟨10.1371/journal.pone.0185753⟩. ⟨hal-01675231⟩

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