P-gp expression levels in the erythrocytes of brown trout: a new tool for aquatic sentinel biomarker development

Abstract : P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant.
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https://hal.archives-ouvertes.fr/hal-01675152
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Submitted on : Thursday, January 4, 2018 - 10:36:09 AM
Last modification on : Friday, April 26, 2019 - 3:55:11 PM

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Emeline Valton, Ivan Wawrzyniak, Christian Amblard, Bruno Combourieu, Marie-Laure Bayle, et al.. P-gp expression levels in the erythrocytes of brown trout: a new tool for aquatic sentinel biomarker development. Biomarkers, Taylor & Francis, 2017, 22 (6), pp.566 - 574. ⟨10.1080/1354750X.2017.1338314⟩. ⟨hal-01675152⟩

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