Immune-Mediated Repair: A Matter of Plasticity

Paôline Laurent (1) , Valérie Jolivel (2) , Pauline Manicki (3) , Lynn Chiu (1) , Cécile Contin-Bordes (1) , Marie-Elise Truchetet (1) , Thomas Pradeu (1)

1 CIRID - Composantes innées de la réponse immunitaire et différenciation
2 BMNST - Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
3 Hôpital Pellegrin

Though the immune system is generally defined as a system of defense, it is increasingly recognized that the immune system also plays a crucial role in tissue repair and its potential dysregulations. In this review, we explore how distinct immune cell types are involved in tissue repair and how they interact in a process that is tightly regulated both spatially and temporally. We insist on the concept of immune cell plasticity which, in recent years, has proved fundamental for the success/understanding of the repair process. Overall, the perspective presented here suggests that the immune system plays a central role in the physiological robustness of the organism, and that cell plasticity contributes to the realization of this robustness.

Domaines: Immunologie; Biologie cellulaire; Biologie du développement

Paôline Laurent, Valérie Jolivel, Pauline Manicki, Lynn Chiu, Cécile Contin-Bordes, et al.. Immune-Mediated Repair: A Matter of Plasticity. Frontiers in Immunology, 2017, 8, pp.454. ⟨10.3389/fimmu.2017.00454⟩. ⟨hal-01673335⟩