Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery

Abstract : Periodic mesoporous ionosilica nanoparticles with ammonium walls were synthesized exclusively from a trisilylated ammonium precursor. The nanoparticles display a uniform particle size, together with a high specific surface area and an ordered hexagonal pore architecture. Completely biocompatible in vitro and in vivo, the nanoparticles are efficiently endocytosed by RAW 264.7 macrophages and used as carrier vehicles for anionic drugs. Diclofenac-loaded ionosilica nanoparticles are very efficient in inhibiting lipopolysaccharides-induced inflammation.
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Submitted on : Sunday, October 29, 2017 - 2:27:17 PM
Last modification on : Wednesday, April 10, 2019 - 5:34:04 PM

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Roza Bouchal, Morgane Daurat, Magali Gary-Bobo, Afitz Da Silva, Leila Lesaffre, et al.. Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2017, 9, pp.32018-32025. ⟨10.1021/acsami.7b07264⟩. ⟨hal-01625845⟩

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