Novel one-step synthesis and characterization of bone-like carbonated apatite from calcium carbonate, calcium hydroxide and orthophosphoric acid as economical starting materials

Abstract : There is growing interest in the development of substituted calcium hydroxyapatite (Ca-HA) for biomedical applications. Carbonated apatite (CAP) appears as an important substituted Ca-HA because of its better biocompatibility compared to pure Ca-HA. This paper reports a novel pressure-mediated one-step synthesis of CAP starting from orthophosphoric acid, calcite and calcium hydroxide as available and high-purity starting materials. Under moderate synthesis conditions (80 degrees C and <13 bar), CAP with different carbonate contents could be obtained. The ratio of calcite/calcium hydroxide mixture played a crucial role for both the advancement of reaction and the carbonate content inserted in CAP's structure. At 80 degrees C, the total decomposition of calcite required a calcite/calcium hydroxide mixture containing at least a half of calcite. CAPs containing 2.25-4.17 wt% of carbonate inserted in its structure were obtained as a function of the composition of calcite/calcium hydroxide mixture. The results open a simple but effective way for the synthesis of high quality biomimetic CAP. (C) 2013 Elsevier Ltd. All rights reserved.
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https://hal.archives-ouvertes.fr/hal-01611993
Contributeur : Imt Mines Albi Ecole Nationale Supérieure Des Mines d'Albi-Carmaux <>
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Doan Pham Minh, Ngoc Dung Tran, Ange Nzihou, Patrick Sharrock. Novel one-step synthesis and characterization of bone-like carbonated apatite from calcium carbonate, calcium hydroxide and orthophosphoric acid as economical starting materials. Materials Research Bulletin, Elsevier, 2014, 51, p. 236-243. 〈http://www.sciencedirect.com/science/article/pii/S0025540813009811〉. 〈10.1016/j.materresbull.2013.12.020〉. 〈hal-01611993〉

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