Physicochemical regulation of TGF and VEGF delivery from mesoporous calcium phosphate bone substitutes

Abstract : Determination of the physicochemical parameters governing growth factors (GFs) adsorption and release from mesoporous calcium phosphate ceramics. Materials & methods: Six mesoporous calcium phosphate ceramics prepared by soft and hard templating were loaded with two different physiological concentrations of TGF-β1 or VEGF165 and their in vitro kinetics of adsorption/release were studied. Results: This low GF loading promotes adsorption on the highest binding sites. The usually encountered detrimental burst release is thus considerably reduced for samples prepared by hardtemplating method. Conclusion: Our findings highlight that the strong affinity of GFs with the ceramic surfaces, demonstrated by a slow GFs release, is enhanced by the large surface area, confinement into mesopores of ceramics and high difference of surface charge between ceramic surfaces and GFs
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Article dans une revue
Nanomedicine, Future Medicine, 2017, 12 (15), pp.1835 - 1850. 〈10.2217/nnm-2017-0158〉
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https://hal.archives-ouvertes.fr/hal-01611676
Contributeur : Brigitte Gaillard <>
Soumis le : vendredi 6 octobre 2017 - 11:32:15
Dernière modification le : jeudi 15 mars 2018 - 01:34:16

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Janina Möller-Siegert, Julien Parmentier, Patrice Laquerriere, Ali Ouadi, Olivier Raissle, et al.. Physicochemical regulation of TGF and VEGF delivery from mesoporous calcium phosphate bone substitutes. Nanomedicine, Future Medicine, 2017, 12 (15), pp.1835 - 1850. 〈10.2217/nnm-2017-0158〉. 〈hal-01611676〉

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