Aedes aegypti larvicidal sesquiterpene alkaloids from Maytenus oblongata

Seindé Touré (1) , Charlotte Nirma (1) , Michaël Falkowski (2) , Isabelle Dusfour (3) , Isabelle Boulogne (2, 4) , Arnaud Jahn-Oyac (2) , Maïra Coke (5) , Didier Azam (5) , Romain Girod (3) , Céline Moriou (1) , Guillaume Odonne (6) , Didier Stien (7) , Emeline Houël (2) , Véronique Eparvier (1)

1 ICSN - Institut de Chimie des Substances Naturelles
2 UMR ECOFOG - Ecologie des forêts de Guyane
3 Institut Pasteur de la Guyane
4 Glyco-MEV - Laboratoire de Glycobiologie et Matrice Extracellulaire Végétale
5 UEEA - Unité d'Ecologie et Ecotoxicologie Aquatiques
6 LEEISA - Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens
7 LBBM - Laboratoire de Biodiversité et Biotechnologies Microbiennes

Four new sesquiterpene alkaloids (1-4) with a beta-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.

Domaines: Sciences du Vivant [q-bio]

Seindé Touré, Charlotte Nirma, Michaël Falkowski, Isabelle Dusfour, Isabelle Boulogne, et al.. Aedes aegypti larvicidal sesquiterpene alkaloids from Maytenus oblongata. Journal of Natural Products, 2017, 80 (2), pp.384-390. ⟨10.1021/acs.jnatprod.6b00850⟩. ⟨hal-01603411⟩