Aedes aegypti larvicidal sesquiterpene alkaloids from Maytenus oblongata

Abstract : Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.
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Seindé Touré, Charlotte Nirma, Michael Falkowski, Isabelle Dusfour, Isabelle Boulogne, et al.. Aedes aegypti larvicidal sesquiterpene alkaloids from Maytenus oblongata. Journal of Natural Products, American Chemical Society, 2017, 80 (2), pp.384-390. ⟨10.1021/acs.jnatprod.6b00850⟩. ⟨hal-01603411⟩



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