Dynamic reorganization of the actin cytoskeleton

Gaëlle Letort (1, 2, 3, 4) , Hajer Ennomani (1, 2, 5, 3) , Laurène Gressin (1, 2, 3, 4) , Laurent Blanchoin (1) , Manuel Théry (1, 2, 3, 4, 6, 7, 8, 9)

1 LPCV - Laboratoire de physiologie cellulaire végétale
2 INRA - Institut National de la Recherche Agronomique
3 CNRS - Centre National de la Recherche Scientifique
4 UJF - Université Joseph Fourier - Grenoble 1
5 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
6 A2T - Alloimmunité-Autoimmunité-Transplantation
7 AP-HP - Hopital Saint-Louis [AP-HP]
8 INSERM - Institut National de la Santé et de la Recherche Médicale
9 UPD7 - Université Paris Diderot - Paris 7

Cellular processes, including morphogenesis, polarization, and motility, rely on a variety of actin-based structures. Although the biochemical composition and filament organization of these structures are different, they often emerge from a common origin. This is possible because the actin structures are highly dynamic. Indeed, they assemble, grow, and disassemble in a time scale of a second to a minute. Therefore, the reorganization of a given actin structure can promote the formation of another. Here, we discuss such transitions and illustrate them with computer simulations.

Mots clés: actin; cytoskeleton; polarization; modelling

Mots clés: actine; cytosquelette; modélisation

Domaines: Sciences du Vivant [q-bio]

Gaëlle Letort, Hajer Ennomani, Laurène Gressin, Laurent Blanchoin, Manuel Théry. Dynamic reorganization of the actin cytoskeleton. F1000Research, 2015, 4, pp.1-11. ⟨10.12688/f1000research.6374.1⟩. ⟨hal-01600852⟩